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1

Antiviral Activities of New Cidofovir Analogs Against Camelpox Virus, Used as a Model of Variola Virus, in Human Skin Equivalent Cultures

Sophie Duraffour, Robert Snoeck, Joost Van Den Oord, Marcela Krecmerová, Antonín Holý, Jean-Marc Crance, Daniel Garin, Erik De Clercq, Graciela Andrei

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 61 KB

english, 2007

2

5-azacytosine compounds in medicinal chemistry: current stage and future perspectives

Krečmerová, Marcela, Otmar, Miroslav

Journal:

Future Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.13 MB

english, 2012

3

Activities of Several Classes of Acyclic Nucleoside Phosphonates against Camelpox Virus Replication in Different Cell Culture Models

Duraffour, S., Snoeck, R., Krecmerova, M., van Den Oord, J., De Vos, R., Holy, A., Crance, J.-M., Garin, D., De Clercq, E., Andrei, G.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2007

Language:

english

File:

PDF, 461 KB

english, 2007

4

Novel and Efficient Synthesis of gem -Difluorinated Derivatives of Acyclic Nucleoside Phosphonates (ANPs)

Pomeisl, Karel, Beier, Petr, Pohl, Radek, Krečmerová, Marcela

Journal:

ChemistrySelect

Year:

2016

Language:

english

File:

PDF, 590 KB

english, 2016

5

Enzymatic Synthesis of Phosphonomethyl Oligonucleotides by Therminator Polymerase

Marleen Renders, Gert Emmerechts, Jef Rozenski, Marcela Krecmerová, Antonin Holý, Piet Herdewijn

Journal:

Angewandte Chemie

Year:

2007

Language:

english

File:

PDF, 146 KB

english, 2007

6

Enzymatic Synthesis of Phosphonomethyl Oligonucleotides by Therminator Polymerase

Marleen Renders, Gert Emmerechts, Jef Rozenski, Marcela Krecmerová, Antonin Holý, Piet Herdewijn

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 147 KB

english, 2007

7

Enzymatic Polymerization of Phosphonate Nucleosides

Marleen Renders, Roel Lievrouw, Marcela Krecmerová, Antonin Holý, Piet Herdewijn

Journal:

Year:

2008

Language:

english

File:

PDF, 304 KB

english, 2008

8

ChemInform Abstract: Inhibitory Potency of 5-Benzyluracil, 5-Phenylcytosine and 5-Phenylpyrimidin-2-one Nucleosides Against Uridine Phosphorylase from Mouse Leukemic L1210 Cells.

Ivan Votruba, Marcela Krecmerova, Hubert Hrebabecky, Antonin Holy

Journal:

Year:

2000

File:

PDF, 31 KB

2000

9

Synthesis of Optically Active N6-Alkyl Derivatives of (R)-3-(Adenin-9-yl)-2-hydroxypropanoic Acid and Related Compounds.

Marcela Krecmerova, Milos Budesinsky, Milena Masojidkova, Antonin Holy

Journal:

Year:

2003

File:

PDF, 125 KB

2003

10

Synthesis of N9- and N7-[2-Hydroxy-3-(phosphonomethoxy)propyl] Derivatives of N6-Substituted Adenines, 2,6-Diaminopurines and Related Compounds.

Marcela Krecmerova, Milena Masojidkova, Antonin Holy

Journal:

Year:

2005

Language:

english

File:

PDF, 31 KB

english, 2005

11

ChemInform Abstract: Syntheses of Antiviral Agents from the Family of Acyclic Nucleoside Phosphonates and Their Prodrugs

Marcela Krecmerova, Antonin Holy

Journal:

Year:

2010

File:

PDF, 15 KB

2010

12

ChemInform Abstract: Synthesis of O2- and N3-(2-Phosphonomethoxy)ethyl Derivatives of 6-Phenyl- and 6-Pyridinyl-5-azacytosine.

Miroslav Otmar, Martin Dracinsky, Marcela Krecmerova, Jan Balzarini, Graciela Andrei, Robert Snoeck

Journal:

Year:

2011

File:

PDF, 28 KB

2011

13

9-(2′-Deoxy-β-D-xylofuranosyl)adenine Building Blocks for Solid-Phase Synthesis and Properties of Oligo(2′-deoxy-xylonucleotides)

Helmut Roscmeycr, Marcela Krečmerova, Frank Seela

Journal:

Helvetica Chimica Acta

Year:

1991

Language:

english

File:

PDF, 877 KB

english, 1991

14

New prodrugs of Adefovir and Cidofovir

Tomáš Tichý, Graciela Andrei, Martin Dračínský, Antonín Holý, Jan Balzarini, Robert Snoeck, Marcela Krečmerová

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 701 KB

english, 2011

15

Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonates using NMR spectroscopy

Martin Dračínský, Marcela Krečmerová, Antonín Holý

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 309 KB

english, 2008

16

Acyclic nucleoside phosphonates with 5-azacytosine base moiety substituted in C-6 position

Marcela Krečmerová, Milena Masojídková, Antonín Holý

Journal:

Bioorganic & Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 350 KB

english, 2010

17

8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase

David Mařák, Miroslav Otmar, Ivan Votruba, Martin Dračínský, Marcela Krečmerová

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 312 KB

english, 2011

18

Synthesis of 3-(4-Pyridinyl)-, 3-(2-Chloro-4-pyridinyl)- and 3-(2-Amino-4-pyridinyl)propoxymethanephosphonic Acid

Krečmerová, Marcela, Holý, Antonín, Masojídková, Milena

Journal:

Collection of Czechoslovak Chemical Communications

Year:

1995

Language:

english

File:

PDF, 111 KB

english, 1995

19

2',3'-Dideoxy- and 3'-Azido-2',3'-dideoxynucleosides of 5-Phenyl-2(1H)-pyrimidinone. Preparation of 2',3'-Dideoxypentofuranoses

Krečmerová, Marcela, Hřebabecký, Hubert, Masojídková, Milena, Holý, Antonín

Journal:

Collection of Czechoslovak Chemical Communications

Year:

1996

Language:

english

File:

PDF, 71 KB

english, 1996

20

ChemInform Abstract: Preparation of 5-Benzyluracil and 5-Benzylcytosine Nucleosides as Potential Inhibitors of Uridine Phosphorylase.

M. KRECMEROVA, H. HREBABECKY, A. HOLY

Journal:

Year:

1996

File:

PDF, 35 KB

1996

21

ChemInform Abstract: 2′,3′-Dideoxy- and 3′-Azido-2′,3′-dideoxynucleosides of 5-Phenyl-2(1H)- pyrimidinone. Preparation of 2′,3′-Dideoxypentofuranoses.

M. KRECMEROVA, H. HREBABECKY, M. MASOJIDKOVA, A. HOLY

Journal:

Year:

1996

File:

PDF, 34 KB

1996

22

ChemInform Abstract: Synthesis of 5-Phenyl-2(1H)-pyrimidinone Nucleosides.

M. KRECMEROVA, H. HREBABECKY, M. MASOJIDKOVA, A. HOLY

Journal:

Year:

1996

File:

PDF, 32 KB

1996

23

ChemInform Abstract: Synthesis of 5-Phenylcytosine Nucleoside Derivatives.

M. KRECMEROVA, H. HREBABECKY, A. HOLY

Journal:

Year:

1996

File:

PDF, 33 KB

1996

24

In Vivo Antiviral Activity of 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine and its Cyclic Form

Graciela Andrei, Marcela Krecmerová, Antonín Holý, Lieve Naesens, Johan Neyts, Jan Balzarini, Erik De Clercq, Robert Snoeck

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 85 KB

english, 2007

25

Synthesis and Antiviral Activity of 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine and its Ester Prodrugs

Marcela Krecmerova, Antonin Holy, Alois Piskala, Graciela Andrei, Robert Snoeck, Lieve Naesens, Johan Neyts, Jan Balzarini, Erik De Clercq

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 74 KB

english, 2007

26

Chemical Stability and Intracellular Metabolism of 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine

Lieve Naesens, Graciela Andrei, Ivan Votruba, Marcela Krecmerová, Antonín Holý, Jan Balzarini, Erik De Clercq, Robert Snoeck

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 50 KB

english, 2007

27

Biochemical Evaluation of a New Potential Antiviral Drug HPMP-5-Azacytosine

Ivan Votruba, Miroslav Hájek, Helena Kaiserová, Eva Tloušťová, Marcela Krečmerová, Antonín Holý

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 79 KB

english, 2008

28

Synthesis and Antiviral Activity of Various N4-Acyl Derivatives of Cidofovir and its 5-Azacytosine Counterpart, 1-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]-5-Azacytosine

Marcela Krecmerova, Antonin Holy, Graciela Andrei, Lieve Naesens, Johan Neyts, Jan Balzarini, Erik De Clercq, Robert Snoeck

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 74 KB

english, 2008

29

Susceptibility of Human Cytomegalovirus (HCMV) Drug-resistant Viruses to a New Class of Acyclic Nucleoside Phosphonate Analogues (ANPs)

Graciela Andrei, Pierre Fiten, Marcela Krecmerova, Antonín Holý, Erik De Clercq, Ghislain Opdenakker, Robert Snoeck

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 71 KB

english, 2008

30

Synthesis of Ester Prodrugs of 9-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]-2,6-diaminopurine (HPMPDAP) as Anti-Poxvirus Agents

Marcela Krecmerova, Antonin Holy, Graciela Andrei, Karel Pomeisl, Tomas Tichy, Genevieve Laflamme, Lieve Naesens, Tomas Cihlar, Johan Neyts, Erik De Clercq, Jan Balzarini, Robert Snoeck

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 105 KB

english, 2010

31

Amido tyrosine esters: a promising new approach to antiviral nucleoside phosphonate prodrugs

Charles E. McKenna, Boris A. Kashemirov, Valeria M. Zakharova, Ivan S. Krylov, Melissa Williams, Marcela Krečmerová, John C. Drach, John M. Hilfinger

Journal:

Antiviral Research

Year:

2011

Language:

english

File:

PDF, 87 KB

english, 2011

32

Alpha anomer of 5-aza-2′-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells

Miroslav Hájek, Ivan Votruba, Antonín Holý, Marcela Krečmerová, Eva Tloušt’ová

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 395 KB

english, 2008

33

Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine

Lieve Naesens, Graciela Andrei, Ivan Votruba, Marcela Krečmerová, Antonín Holý, Johan Neyts, Erik De Clercq, Robert Snoeck

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 570 KB

english, 2008

34

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents

Marcela Krečmerová, Martin Dračínský, Dana Hocková, Antonín Holý, Dianne T. Keough, Luke W. Guddat

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 533 KB

english, 2012

35

An enzymatic glycosylation of nucleoside analogues using β-galactosidase from Escherichia coli

Jiří Blažek, Petr Jansa, Ondřej Baszczyňski, Martin Maxmilian Kaiser, Miroslav Otmar, Marcela Krečmerová, Martin Drančínský, Antonín Holý, Blanka Králová

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.05 MB

english, 2012

36

Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives

Petr Potměšil, Marcela Krečmerová, Eva Kmoníčková, Antonín Holý, Zdeněk Zídek

Journal:

European Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 576 KB

english, 2006

37

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: A target for anti-malarial chemotherapy

Dianne T. Keough, Dana Hocková, Marcela Krečmerová, Michal Česnek, Antonín Holý, Lieve Naesens, Ian M. Brereton, Donald J. Winzor, John de Jersey, Luke W. Guddat

Journal:

Molecular and Biochemical Parasitology

Year:

2010

Language:

english

File:

PDF, 205 KB

english, 2010

38

Synthesis of O2- and N3-(2-Phosphonomethoxy)ethyl Derivatives of 6-Phenyl- and 6-Pyridinyl-5-azacytosine

Otmar, Miroslav, Dracinsky, Martin, Krecmerova, Marcela, Balzarini, Jan, Andrei, Graciela, Snoeck, Robert

Journal:

Year:

2011

Language:

english

File:

PDF, 736 KB

english, 2011

39

Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety

Tichý, Tomáš, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan, Dračínský, Martin, Krečmerová, Marcela

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 371 KB

english, 2012

40

Selected polyhalogenated hydrocarbons in breast milk

V. Bencko, Z. Skulová, M. Krečmerová, A.K.Djien Liem

Journal:

Toxicology Letters

Year:

1998

Language:

english

File:

PDF, 61 KB

english, 1998

41

9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: Optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro

Krečmerová, Marcela, Jansa, Petr, Dračínský, Martin, Sázelová, Petra, Kašička, Václav, Neyts, Johan, Auwerx, Joeri, Kiss, Eleonóra, Goris, Nesya, Stepan, George, Janeba, Zlatko

Journal:

Bioorganic & Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 993 KB

english, 2013

42

Synthesis of Optically Active N6-Alkyl Derivatives of (R)-3-(Adenin-9-yl)-2-hydroxypropanoic Acid and Related Compounds

Krečmerová, Marcela, Buděšínský, Miloš, Masojídková, Milena, Holý, Antonín

Journal:

Collection of Czechoslovak Chemical Communications

Year:

2003

Language:

english

File:

PDF, 163 KB

english, 2003

43

Synthesis of N9- and N7-[2-Hydroxy-3-(phosphonomethoxy)propyl] Derivatives of N6-Substituted Adenines, 2,6-Diaminopurines and Related Compounds

Krečmerová, Marcela, Masojídková, Milena, Holý, Antonín

Journal:

Collection of Czechoslovak Chemical Communications

Year:

2004

Language:

english

File:

PDF, 214 KB

english, 2004

44

Inhibition of the Escherichia coli 6-Oxopurine Phosphoribosyltransferases by Nucleoside Phosphonates: Potential for New Antibacterial Agents

Keough, Dianne T., Hocková, Dana, Rejman, Dominik, Špaček, Petr, Vrbková, Silvie, Krečmerová, Marcela, Eng, Wai Soon, Jans, Harmen, West, Nicholas P., Naesens, Lieve M. J., de Jersey, John, Guddat, Lu

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 4.95 MB

english, 2013

45

Transdermal Delivery and Cutaneous Targeting of Antivirals using a Penetration Enhancer and Lysolipid Prodrugs

Diblíková, Denisa, Kopečná, Monika, Školová, Barbora, Krečmerová, Marcela, Roh, Jaroslav, Hrabálek, Alexandr, Vávrová, Kateřina

Journal:

Pharmaceutical Research

Year:

2014

Language:

english

File:

PDF, 314 KB

english, 2014

46

N4-Acyl derivatives as lipophilic prodrugs of cidofovir and its 5-azacytosine analogue, (S)-HPMP-5-azaC: Chemistry and antiviral activity

Krečmerová, Marcela, Pohl, Radek, Masojídková, Milena, Balzarini, Jan, Snoeck, Robert, Andrei, Graciela

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 605 KB

english, 2014

47

National prevalence survey of hospital-acquired infections in Czechoslovakia

Šrámová, H., Bartoňová, A., Bolek, S., Krečmerová, M., Šubertová, V.

Journal:

Journal of Hospital Infection

Year:

1988

Language:

english

File:

PDF, 379 KB

english, 1988

48

Safety Assessment in Pigs of an Experimental Molecule with In-Vitro Antiviral Activity Against African Swine Fever

Roels, S., Van der Heyden, S., Neyts, J., Krečmerová, M., Koenen, F., Cay, A.B., Tignon, M.

Journal:

Journal of Comparative Pathology

Year:

2013

Language:

english

File:

PDF, 61 KB

english, 2013

49

Enhancing of enzymatic palmitoylation of racemic 9-(2,3-dihydroxypropyl)adenine in co-solvent mixture as the reaction media

Brabcova, Jana, Blazek, Jiri, Krecmerova, Marcela, Zarevucka, Marie, Palomo, Jose M.

Journal:

New Biotechnology

Year:

2014

Language:

english

File:

PDF, 63 KB

english, 2014

50

Inhibitory Potency of 5-Benzyluracil, 5-Phenylcytosine and 5-Phenylpyrimidin-2-one Nucleosides Against Uridine Phosphorylase from Mouse Leukemic L1210 Cells

Votruba, Ivan, Krečmerová, Marcela, Hrˇebabecky´, Hubert, Holý, Antonín

Journal:

Nucleosides and Nucleotides

Year:

1999

Language:

english

File:

PDF, 612 KB

english, 1999

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